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Flip flopping cellular receptors
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G protein-coupled receptors (GPCRs) are cellular nanomachines that can transmit signals. They act as a communication interface between the external and internal environments of the cell. It is important to study how modifications of GPCRs affect the cellular communication and thus, the cellular functions.
Palmitoylation of GPCRs is a process in which a palmitoyl group is covalently added to the GPCR. In this collaborative work with Durba Sengupta of CSIR-NCL, Amitabha Chattopadhyay explored the change in lipid (cholesterol and phospholipids) interactions with palmitoylation of the glucagon-like peptide-1 receptor (GLP-1R), a GPCR which acts as a drug target in diabetes and obesity.
They show here that both cholesterol and phospholipids interact with GLP-1R. But they exhibit differential interactions in the presence and absence of the palmitoyl chain, implying differences in signalling by the receptor under these conditions.
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What formed the Ladakhi population?
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In the high-altitude valley of Ladakh, formed of a few major communities. How were these communities formed? Recent study from K Thangaraj's lab in collaboration with Niraj Rai at DST-Birbal Sahni Institute of Paleosciences show that Changpa and Monpa tribes share a common maternal genetic ancestor with affinity to Tibeto-Burman speakers. On the other hand, Brokpas are the most ancient settlers of this region with mitochondrial lineage going back to Neolithic period.
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Pradeep Kumar for being one of the finalists of the Inspiring Science Award by TNQ Technologies
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Sitanshu Sarangi for being one of the finalists of the Inspiring Science Award by TNQ Technologies
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Tuhina Prasad for the best poster award at the 46th All India Cell Biology Conference at Cancer Research Community of Actrec - TMC
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Pratheusa Machha for the Student Scholarship Award at the 48th Annual Meeting and International Conference of the Indian Society of Human Genetics, ISHG 2024
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Yogesh Sardana and Khyathi Ratna for the best poster prize at The Future is Here: Gene Therapy, Cell Therapy & Biomaterials in Opthalmology conference at LV Prasad Eye Hospital
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India Asks Why - the world is as it is
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Join the India Asks Why team to ask questions that you might have always wondered about but thought they are too naive to ask anyone. They will have your questions answered by expert scientists demystifying your questions, be it about your dreams or kicking babies in the wombs of expecting mothers.
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Making science storybooks
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Students from CCMB, CDFD and University of Hyderabad came together with Ipsa Jain to build a storybook for children to tell a story of shape of atoms. We will put out their story soon.
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Young Innovators Program 2024 gets more inclusive
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26 students from government and private schools of Hyderabad and beyond joined us at the week-long Young Innovators Program 2024 discussing research that happens at CCMB while doing hands-on experiments of genetics to microbiology to structural biology.
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Taking science to public spaces
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It's time to take science to public spaces so that we reach public who do not find themselves in science institute spaces for any reason. The Hyderabad Literary Fest 2024 introduced a new stream, Science and the City, that brought our students and scientists face to face with citizenry to discuss their work in the context of questions that public think is worthwhile.
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If you have enjoyed reading the CCMB Daak, do subscribe and share it with your friends and colleagues!
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Please send us your feedback at socialmedia[at]csirccmb[dot]org. Looking forward to them.
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