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The Daak takes us through stories of evolution, how our scientists are trying to make sense of them, and thus, the world around us.
Cover art by Freya Hartas in Aquila magazine.

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Primate genome sequencing to understand evolution and health
Two global studies on genome sequencing of 233 primate species, with G Umapathy's lab as collaborators from India, provide new data on primate evolution, including humans. These studies help us understand evolution of primates better, and build insights on health as well as conservation.
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Centipedes in Western Ghats help establish the rules of evolution
How does genetic diversity come about in populations? Does the size of their population matter? Or the body size of individuals? Jahnavi Joshi and her lab address these questions to understand the underlying factors of genetic diversity in their recent study in centipedes, the ancient arthropods that have been around for 400+ million years.
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Ways that plants have chosen differently from other eukaryotes
Bacteria and archaea have emerged and evolved independently for ~4 billion years. While eukaryotic cells were first formed by ingestion of an alphaproteobacteria by an archaeal cell ~2 billion years ago. Our earlier findings showed that the proofreading machinery associated with protein synthesis factory of bacteria is incompatible with archaea. Therefore, the optimisation of error correcting machinery from both bacteria and archaea to work with each other in eukaryotes was essential.
We found that two major life forms, animals and plants resorted to two independent solutions to tackle these incompatibilities. Animals have used a single bacterial component and optimised the rest of protein synthesis apparatus whereas plants have restricted the movements of conflicting components in different sections of the cell.
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Growth of bacterial cell envelope - a synchronous growth of multiple layers
The cell envelope of bacteria is a complex multi-layered structure that serves to protect them from the harsh environmental conditions.
The Gram-negative bacterial cell envelope consists of a peptidoglycan layer sandwiched between two lipid-rich membranes. During growth of bacteria, synchronized expansion of these layers is critical for the envelope integrity.
A recent study by Nilanjan Som in Manjula Reddy's laboratory identifies an interesting cross-talk between the membrane and peptidoglycan synthesis that allows a coupled expansion of the multi-layered envelope. This study contributes to the understanding of the bacterial cell wall, which is a target of several clinically important antibiotics.
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Creating advocates for genetic disease testing


On the occasion of World Sickle Cell Awareness Day, GR Chandak spoke on how their lab is working towards sickle cell anemia diagnostics and treatment.
What makes reliable genetic tests?
Genetic testing promises to prevent many genetic diseases. But how exactly? Are there aspects of it that need improvement? Sara Sajjadi addresses these in her article on SciTales.
The Gene-Health Connect can be at your doorstep!
To know more on genes and how it is connected with health, the Gene-Health Connect is a friendly resource. Co-developed by CCMB and VITM, the Gene-Health Connect is a mobile exhibition that is going from campus to campus talking raising conversations on how genes and health are connected with each other, the possibilities that present technologies offer us, and the areas that need more work and understanding.
If you are an educational institute in Telangana or Andhra Pradesh, and would like the bus on your organization/community's premises, please register here.
Scientists from CSIR and Institut Pasteur seek collaborations
Scientists from CSIR labs and Institut Pasteur, Paris with expertise on human health and diseases came together to find overlapping interests in AMR, emerging and reemerging diseases and preparedness, and human genetics and genomics. This paves the way for collaborative research projects, and eventually a joint research centre at CCMB!
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Empowering healthcare innovators - Navigating IP landscape
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Writers and scientists come together
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