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Daak brings you life science research at all scales at CCMB. Cover art: Mitchell's equation by Odra Noel, inspired by the chemiosmotic hypothesis that penetrates all biology, Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
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How are DNA repair and multidrug resistance linked in bacteria?

Cells have DNA repair genes to ensure that the DNA sequences remain the same across cell generations. A recent study from Vinay Nandicoori's lab correlates polymorphisms in DNA repair genes and emergence of multidrug resistance in bacteria.

Understanding COVID-19 outcomes, molecule by molecule
Regulation of various cytokines and proteins have been of interest to researchers to understand the basis of SARS-CoV-2 infection. In a recent study, Mohammed Idris’ group in collaboration with Nagaraj describe the regulation and involvement of these molecules during SARS-CoV-2 infection in humans. Of particular interest is the up-regulation of Annexin 2 that is involved in auto-immune response, during COVID infection.
The master controllers of our body structures
Hox genes are known to design the head-tail axis of developing bilaterian embryos. The arrangement of these genes on chromosomes mimics their expression along the body axis. That means, the first gene in the Hox gene cluster expresses more anterior of the body than the second, and so on.
In a recent study, Rakesh Mishra's lab rearranged some of these Hox genes in fruitflies. Check out some astonishing changes they see in the flies.
Passage of memory in dividing cells
How do dividing cells re-organize themselves to function similarly as their mother cell? There is to be a molecular memory, the mitotic memory, that guides the daughter cells. This memory manifests in form of DNA modifications, histone modifications, RNA, and proteins.
In the recent review by Rakesh Mishra's lab, they discuss how the nuclear matrix is packaged into the mitotic chromosomes, and acts as the carrier of mitotic memory to seed the reorganization of the daughter nuclei.
What tells the proteins how they should be built?
Cells have to ensure they choose the right amino acids to build proteins. Right not only in their composition but also in their 3D structures. Check out how a protein DTD helps in this process.
How to observe the brain during its development?
Given our lack of ability to look into human brains during their development or disease, scientists have to work with various model systems appropriate to the questions being addressed. In this review, Megha Kumar and her lab compare the different in vivo model systems available for studying development and disorders of the nervous system.
Designing your own model system
Fruitflies have been a long-time favorite model system for many biologists. Check out how scientists have been using them to address many questions.
Politics of ancient DNA research
Ancient DNA research is helping us solve many mysteries of past, be it of humans or other living forms on earth. But the field has a deep Global North-Global South divide, and needs attention on, say researchers from Vasant Shinde's group in this review.
mRNA vaccine - India's next potion in healthcare
In our Technologies We Need Now series, Kasturi Mahadik discusses mRNA vaccines with Madhusudhana Rao. Started at Atal Incubation Centre - CCMB during COVID-19, the technology and the infrastructure can now be utilized against many other diseases.
Read here
Many congratulations to

Saikat Chowdhury for the "Excellence in Microscopy Award" from the Electron Microscope Society of India (EMSI) at University of Delhi.

CG Gokulan for the Best Poster Awards at the 2nd Indian Rice Congress at ICAR-National Rice Research Institute, Cuttack and the International Conference on Current Trends and Future Prospects of Plant Biology at University of Hyderabad.

Kamal Kumar Malukani for the 2nd prize in poster presentation at the International Conference on Current Trends and Future Prospects of Plant Biology at University of Hyderabad.


Sneha Paturi for the best oral presentation award at the National Magnetic Resonance Society Meeting held at IISER, Behrampur.
Our PhD applications are open NOW!
If you have a Master’s degree in any branch of science or a Bachelor’s degree in Engineering/Pharmacy/Medicine, you are eligible to apply for our PhD program. Application closes on 20th March.
Apply now
Founder's Day - An occasion to meet our alumni
CCMB celebrated its Founder's Day on 22 Feb. But this year, it also conducted its first formal alumni meeting on 21 Feb. With our alumni from different parts of India and abroad, our PhD students could discuss different facets of STEM careers.
Taking it ahead with communities
The first CCMB Science Festival happened on 28 Feb, on the occasion of National Science Day. The pilot with about 25 colleges from Hyderabad this year has set the tone for a bigger festival next year.
While DNA is at the core of the most scientific questions addressed at CCMB. At the same time, we realize that many of these concepts appear in school textbooks without enough context. This gave rise to the genesis of our teachers workshop - Learn DNA, Teach DNA for the high school teachers of Telangana.
Thanks to the Telangana State Judicial Academy, 35 newly appointed judges visited CCMB to understand how DNA fingerprinting and wildlife forensic technologies help us solve conflicts.
From young students and educators to those evaluating and utilizing life science technologies to connecting with our own older colleagues, February had it all.
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