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February is our month to celebrate the Founder Director PM Bhargava's vision that laid the foundation for CCMB, which grew with capable leadership over decades. Cover art by Argha Manna.
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A day to connect with our alumni - Founder's Day
On 22 Feb, we celebrated our 6th Founder's Day bringing together our past and present students together. Alumni Rana Anjum and Suresh Chintalapati spoke of their career paths - challenges and resolutions that came their way. K VijayRaghavan spoke of how Indian research institutes can benefit from an overhaul that would let young students explore more independently. Plus there were talks from CCMB students on some of the exciting questions in life sciences.
See the sessions
What does it take to regenerate?
Regeneration of organs/tissue is complex and involves differential regulation and expression of several genes and proteins. The latest study by Mohammed Idris's lab has identified 1408 genes and 661 proteins to be involved in regeneration of zebrafish caudal fin tissue which is similar to human appendages. Through high-throughput transcriptomics and proteomics analyses the study have identified Interleukin, Solute carrier, Protein arginine methyltransferase, Homeobox, Neurotransmitter and several novel genes/proteins families to be associated in epimorphic regeneration of the fin tissue. This work also discovered activation of cell proliferation, cell viability, cell survival & cell death network pathways to be associated with regeneration.
How do Mycobacteria enter cells?
Macrophages are the primary hosts for Mycobacterium tuberculosis, the causative agent of human tuberculosis. Using the surrogate Mycobacterium smegmatis model, the Raghunand Tirumalai and Amitabha Chattopadhyay labs show a quantitative relationship between actin polymerization in human macrophages and Mycobacterial entry: less F-Actin strongly correlates with reduced entry. This work highlights actin-mediated mycobacterial entry as a potential target for future anti-TB therapeutics.
Complexities of immunity
Microbial attack and immunity make a complex war field. Plant pathogens secrete effector proteins into their host plant cells. Some of these proteins are known to compromise the host's immune responses. However, some rare combinations of these proteins also elicit immune responses in plants. The recent study from Ramesh Sonti's group discusses the mechanistic details of how one effector protein, XopG suppresses immune responses elicited by other bacterial effector proteins in rice plants.
Resolving challenges of nucleic acid-based paper diagnostic devices
In the last two years, nucleic acid (DNA and RNA) based diagnostic tests have gained increasing attention. Paper-based diagnostic devices have also been developed in this direction. However, most of the steps in nucleic acid based testing need use of at least a water bath. In this study, Tripura et al show how one of the steps - reverse transcription (converting RNA to DNA) can be performed at room temperature on a ready-to-use cellulose paper-device.
Many congratulations



GR Chandak for the JC Bose fellowship. He focuses on understanding the genetics and epigenetics of complex diseases such as diabetes and pancreatitis.

B Kiran Kumar and collaborators from IIT Hyderbad and LV Prasad Eye Institute for their Sree RamaKrishna Parahamsa Research Grant 2021 award to try a biomimetic hydrogel for the treatment of blinding corneal diseases.
How can insects be used to study brain and behavior?
Runa Hamid writes of her academic journey with studying fruitfly brains, the interplay between the neurons in their brains and a hope to study neuropsychiatric diseases.
Read here
India Asks Why tigers have stripes
Join team India Asks Why and Mihir Trivedi as they answer the question among their many other deep basic questions that we tend to overlook.
Listen here
CCMB Biologue - Meet life science experts across the world
Join Uma Ramakrishnan in her studies of genetics in tigers of India.
Join Fiona Watt in discussing the power of single-cell technologies behind the Human Cell Atlas.
Shadow a Scientist - at CCMB
Apply here
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