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This Daak celebrates the new year ahead with promises of many excitements of science and newer ways of reaching out to the society. Happy New Year 2023!
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Reproductive physiology for conservation breeding

Umapathy’s group characterized the reproductive behavior of mouse deer in captivity. This was important for conservation breeding of mouse deer. In the study, they found mouse deer shows the shortest post-partum estrus period, during which the female mouse deer shows estrus and mates within 4-6 hrs of delivery.

While analysing the hormone profiles, they discovered 16-androstenes sex pheromones (androstenone and androstanol) in mouse deer. They examined molecular characteristics of these pheromones, their synthesis pathway and functions in the mouse deer reproduction.
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What happens to bacteria in cold?
Recent study from Manjula Reddy’s lab has found how the peptidoglycan (PG) layers (below the cell membranes) in bacterial cells change in response to cold. The PG layer is made of short peptide chains, inter-connected to each other. There are two kinds of cross-links, called the 4-3 and 3-3 crosslinks (shown as a and b respectively in the image). Upon a cold shock, the 3-3 crosslinks increase, which the researchers think make the cells more resilient towards cold.
How an immune response protein functions in cells

Effector immune cells, such as T cells and natural killer cells, protect us against infection or cell transformation. They detect abnormal changes at the surface of other cells using receptors. Some of these receptors are called inhibitory; they restrain cytotoxicity of natural killer cells by binding to ligands on healthy cells and signaling through phosphorylation of tyrosine amino acid in its cytosolic tail. Santosh Kumar’s group looked into the mechanism of phosphorylation of these tyrosines.
In their recent paper, they found that the process is regulated by electrostatic interaction between the receptor’s cytosolic tail with the plasma membrane despite the tail’s overall neutral charge. The unique mode of engagement with the plasma membrane, shown by the intrinsically disordered (ID) KIR tail, has several unusual features: i) it allows an electrically neutral region to interact electrostatically with the plasma membrane, ii) it does not induce helix formation in the ID region, and iii) it confers to the ID region intrinsic abilities of both binding to and unbinding from the plasma membrane. Our results, on how this unusual electrostatic interaction regulates signaling, advance understanding of immune responses by inhibitory receptors and the biology of protein ID regions.

Immunity and autophagy working together




Study from Santosh Chauhan's lab shows unique mechanism where the innate immune proteins and autophagy machinery are recruited together to the bacteria for defense as well as for maintaining immune homeostasis.
Many congratulations to



Dhananjay Chaturvedi for the DBT-Wellcome India Alliance's Intermediate fellowship.
 



Ishwariya Venkatesh for joining as a Senior Scientist at CCMB.



Giriraj Chandak on his joining the Public Health Foundation of India as an Adjunct Faculty.


Akshay Bhatnagar, former postdoc at CCMB, selected as the finalist for Inspiring Science Award by TNQ Technologies.



Priti Behra from Mandar Deshmukh's group for the Best Poster Award at the India|EMBO Lecture Course on Structure, dynamics and interactions in biomolecular systems using NMR spectroscopy at Berhampur.

Yogesh Sahu from  Ishwariya Venkatesh's group for the Best Poster Award at the Indian Academy of Neurosciences meeting at Neru, Shillong.


Aman Kumar Suryan from Karthik Bharadwaj's group for a Consolation Prize for Oral Presentation at the 7th Annual Conference of Society for Indian Academy of Medical Genetics.
Technologies we need NOW
In our new series, Technologies We Need NOW, Ketaki Bhagwat interviews Archana Bharadwaj Siva on how wastewater surveillance can help cities in tracking and preventing diseases.
Read here
Back to the past - From somatic cells to stem cells
Stem cells are powerful - they can make any cell from the many hundred kinds that our bodies have. But did you know that our body cells can also be converted into stem cells in labs? Check out the recent article by Tanishqa Chaubal on how and why scientists are converting the normal body cells to stem cells.
Read here
Why do snakes not have limbs?
When we have limbs, why do some animals not have them? Did they never have them? Or did they lose it over the course of evolution? Can we also lose our limbs? Check out the latest India Asks Why podcast to know more.
Listen here
Ladakh's Lt Governor at CCMB
Ladakh Lt Governor, Mr Radha Krishna Mathur visited CCMB. He went through our cutting edge research facilities and understood our research focus areas. Discussions with him benefited us immensely on understanding how to develop technologies that are useful and accessible to society.
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Young Innovators Program-2023 is all set to start
CCMB is all set for its 10th Young Innovators Program. The program inaugurated with a public lecture by Ullas Kolthur, TIFR on food and metabolism, followed by a selection test for the students. 26 out of roughly 200 participants have now been selected for hands-on sessions at CCMB from 4-13 Jan, 2023.
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